The sense of play lies at the roots of learning

Eric Westhof

doi:10.12405/j.issn.2097-1486.2024.02.003

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The sense of play lies at the roots of learning

更新时间：2024-11-05

- The sense of play lies at the roots of learning
- The sense of play lies at the roots of learning
- 新兴科学和技术趋势 2024年3卷第2期页码：146-157
- 作者机构：
  
  Wenzhou Institute， University of Chinese Academy of Sciences， Wenzhou， 325001， China
- 作者简介：
  
  [ "Eric Westhof is member of the French Academy of Sciences， the German Academy of Sciences Leopoldina，the European Molecular Biology Organization （EMBO）， the Academia Europaea， the association of French and Chinese experts. Principal researcher at the Wenzhou Institute of the University of the Chinese Academy of Sciences， visiting professor at Southwest University （Chongqing）， emeritus professor at the University of Strasbourg， and the President-delegate of the Cercle Gutenberg in France. He has served as Vice President for Research at the University of Strasbourg，Delegate for Education and Training at the French Academy of Sciences （2016—2023）， President of the French Society of Biochemistry and Molecular Biology， President of the InternationalRNA Society. He is now member of the Scientific Advisory Board of the 《RNA Institute》， Albany， NewYork， USA， of the“ International Advisory Board” of the International Institute of Molecular and Cell Biologyin Warsaw（Poland）， and of the International Scientific Advisory Board of the Faculty of Medicine at theUniversité de Montréal.His work has extended physicochemical characterization， structural and folding studies of RNAs to theirfunctional and evolutionary aspects and predicted interactions with specific molecules of therapeutic interest. Hehas developed several structural models of catalytic RNAs， revealing many rules for RNA folding and selfassembly.He modeled catalytic RNAs prior to their experimental determination， especially of group I introns（the“Michel-Westhof”model）and introduced the “Leontis-Westhof” RNA base-pairing nomenclature toannotate all types of base pairs in nucleic acids. Since 2010， he is organizing RNA-Puzzles， an internationalcompetition to evaluate the blind prediction of 3D RNA structures.He has received several major French and international awards， including the Jacques Monod Prize，thePrize Charles-Léopold Mayer，the Oustanding Service Award of the RNA Society， the Feodor Lynn Medal ofthe German Society for Biochemistry and Molecular Biology， the Rolf Sammet Prize of the Johann WolfgangGoethe University Frankfurt， Ying-Lai Wang Lecturer， Shanghai Institute of Biochemistry and Cell Biology，Chinese Academy of Sciences， China， the Datta Medal of the Federation of European Biochemical Societiesand the Lifetime Achievement Award of the International Society for RNA.According to Web of Science，he has published 477 papers（ 32 760 citations，h-index=97）， of which 23are in the “Nature family journals” and 11 in “Science”. In the 2022 ScholarGPS Global Highly RankedScholars， he was ranked fifth in the field of RNA.He has co-edited 4 books and is a member of the editorial boards of several internationally recognizedacademic journals，including Associate Editor of RNA， Executive Editor of Nucleic Acids Research at OxfordUniversity Press，Executive Editor of Wiley’s Journal of Molecular Recognition， Executive Editor of Elsevier’sBiochemical and Biophysical Research Communications." ]
- 基金信息：
- DOI：10.12405/j.issn.2097-1486.2024.02.003
  中图分类号：
- 纸质出版日期：2024-06-15，
  
  收稿日期：2024-04-10，
  
  修回日期：2024-05-07，
- 稿件说明：
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Eric Westhof. The sense of play lies at the roots of learning[J]. 新兴科学和技术趋势, 2024,3(2):146-157.

Westhof Eric.The sense of play lies at the roots of learning[J].Emerging Science and Technology,2024,3(2):146-157.
Eric Westhof. The sense of play lies at the roots of learning[J]. 新兴科学和技术趋势, 2024,3(2):146-157. DOI： 10.12405/j.issn.2097-1486.2024.02.003.

Westhof Eric.The sense of play lies at the roots of learning[J].Emerging Science and Technology,2024,3(2):146-157. DOI： 10.12405/j.issn.2097-1486.2024.02.003.

摘要

Abstract

In a famous book， Johann Huizinga referred to

Homo sapiens

（“thinkers”） as

Homo ludens

（“players”）. Here I try to foster an appreciation of the importance of play in the learning process， not only during childhood but continuously afterwards. Play is a major biological incentive for generating pleasure during learning and helps to accept the challenges and to overcome the difficulties attached to any intellectual effort or work. Play is rooted in the randomness of interactions between participants， with chance channeled by the rules of the game. Parallels with Darwinian evolution based on chance （randomness of mutations and changes in conditions） and necessity （the physico-chemical rules） are made. The development of science-based challenges or computer games and their roles in citizen-oriented science are also described. Some basic concepts of RNA structural biology illustrating the text are explained.

“Play is the work of childhood”， Jean Piaget.

“Every game has its rules”， Johann Huizinga.

关键词

Keywords

science teachinggameRNAevolutionstructuresequencesalignment

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