两亲性聚集诱导发光荧光探针设计策略及应用

刘继红; 王雨薇; 王琪; 朱为宏

doi:10.12405/j.issn.2097-1486.2024.02.001

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两亲性聚集诱导发光荧光探针设计策略及应用

更新时间：2024-11-05

- 两亲性聚集诱导发光荧光探针设计策略及应用
- Design strategy and application of amphiphilic aggregation-induced emission fluorescent probe
- 新兴科学和技术趋势 2024年3卷第2期页码：101-127
- 作者机构：
  
  结构可控先进功能材料及其制备教育部重点实验室，华东理工大学化学与分子工程学院，上海 200237
- 作者简介：
  
  [ "王琪，教授，博士生导师，国家优秀青年基金获得者，上海市“浦江人才”。获授权中国专利7项，在Adv. Mater.、Adv. Funct. Mater.、Natl. Sci. Rev.、CCS Chem.、Chem. Sci.、Biomaterials等杂志上发表SCI论文50余篇。先后入选中国抗癌协会纳米肿瘤学专业委员会委员、中国医药生物技术协会造影技术分会委员、上海市药学会会员、上海药学会药剂学青年专委会委员、中国医药卫生文化协会医工融合分会委员。Email： wangqi@ecust.edu.cn" ]
  [ "朱为宏，教授，博士生导师，中国科学院院士。现任华东理工大学副校长、精细化工研究所所长。国家杰出青年基金获得者，科技部重点研发项目首席科学家，曾入选教育部长江学者特聘教授、中组部万人计划科技创新领军人才、国务院特殊津贴专家、上海市科技精英、教育部新世纪优秀人才、上海市学术带头人。迄今已在Science、Nature、Nature Photonics、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Chem、Adv. Mater.、Matter、Nature Commun.、Energy Environ. Sci.、National Science Review等期刊上发表SCI论文350余篇，共被SCI引用近2.5万余次，H指数为84，科睿唯安化学领域“高被引科学家”。申请中国发明专利36项，其中28项已授权，曾获国家自然科学奖二等奖两项、上海市自然科学奖一等奖两项、上海市科技进步奖一等奖、上海市牡丹奖等。Email： whzhu@ecust.edu.cn" ]
- 基金信息：
  
  国家重点研发计划(2021YFA0910000);国家自然科学基金优秀青年基金(22222803);博士后创新人才支持计划(BX20240114)
- DOI：10.12405/j.issn.2097-1486.2024.02.001
  中图分类号： O632
- 纸质出版日期：2024-06-15，
  
  收稿日期：2024-04-07，
  
  修回日期：2024-05-24，
- 稿件说明：
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刘继红,王雨薇,王琪等.两亲性聚集诱导发光荧光探针设计策略及应用[J].新兴科学和技术趋势,2024,3(2):101-127.

LIU Jihong,WANG Yuwei,WANG Qi,et al.Design strategy and application of amphiphilic aggregation-induced emission fluorescent probe[J].Emerging Science and Technology,2024,3(2):101-127.
刘继红,王雨薇,王琪等.两亲性聚集诱导发光荧光探针设计策略及应用[J].新兴科学和技术趋势,2024,3(2):101-127. DOI： 10.12405/j.issn.2097-1486.2024.02.001.

LIU Jihong,WANG Yuwei,WANG Qi,et al.Design strategy and application of amphiphilic aggregation-induced emission fluorescent probe[J].Emerging Science and Technology,2024,3(2):101-127. DOI： 10.12405/j.issn.2097-1486.2024.02.001.

摘要

荧光探针具有灵敏度高、成本低廉、响应快速和可原位实时监控等优点，是生物学和医学等众多领域的重要研究手段。与传统具有聚集诱导淬灭效应的荧光探针相比，聚集诱导发光（Aggregation-induced emission，AIE）荧光探针展示出了使用浓度范围宽、光稳定性好、分辨率高等显著优势。两亲性AIE荧光探针进一步提升了生物相容性、靶向性和检测信噪比，在生物化学检测领域展示出很大的潜力。本文以两亲性AIE荧光探针的分子设计为出发点，从ROS与GSH检测、金属离子检测、活性酶检测、细胞器成像、肿瘤诊断、肿瘤光动力治疗六个方面总结了其在化学传感与生物应用领域的最新研究进展，并对未来的发展方向与前景进行了展望。

Abstract

Fluorescent probes， having the advantages of high sensitivity， low cost， fast response， in situ monitoring and real-time imaging， are imperative research tools in many fields such as biology and medicine. Compared with traditional fluorescent probes， which having the aggregation-induced quenching effect， aggregation-induced emission （AIE） fluorescent probes show the significant merits of wide application concentration， good photostability and high resolution. Amphiphilic AIE fluorescent probes further improve biocompatibility， targeting， and signal-to-noise ratio of detection， and show great potentials in the field of biochemical detection. Starting from the molecular design of amphiphilic AIE fluorescent probes， this paper summarizes the latest research progress in the field of chemical sensing and biological applications from six aspects： ROS and GSH detection， metal ion detection， active enzyme detection， organelle imaging， tumor diagnosis， tumor photodynamic therapy. In the end， it looks forward to the prospect and the future development directions.

关键词

荧光探针聚集诱导发光两亲性生物成像

Keywords

fluorescence probeaggregation-induced emissionamphiphilicbioimaging

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WANG J， ZHU X， ZHANG J， et al. AIE-based theranostic agent： In situ tracking mitophagy prior to late apoptosis to guide the photodynamic therapy［J］. ACS Applied Materials & Interfaces， 2020， 12（2）：1988-1996. DOI：10.1021/acsami.9b15577http://dx.doi.org/10.1021/acsami.9b15577.

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CHENG G， WANG H， ZHANG C， et al. Multifunctional nano-photosensitizer： A carrier-free aggregation-induced emission nanoparticle with efficient photosensitization and pH-responsibility［J］. Chemical Engineering Journal， 2020， 390：124447. DOI：10.1016/j.cej.2020.124447http://dx.doi.org/10.1016/j.cej.2020.124447.

SAURAJ， KANG J H， LEE O， et al. Novel aggregation-induced emission-photosensitizers with built-in capability of mitochondria targeting and glutathione depletion for efficient photodynamic therapy［J］. Nanoscale， 2023， 15（10）： 4882-4892. DOI：10.1039/D2NR06593Bhttp://dx.doi.org/10.1039/D2NR06593B.

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