荧光探针与高信噪比活体荧光成像

岳永康; 阴彩霞

doi:10.12405/j.issn.2097-1486.2023.02.001

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荧光探针与高信噪比活体荧光成像

更新时间：2024-03-29

- 荧光探针与高信噪比活体荧光成像
- Fluorescent probes for high signal-to-noise ratio in vivo imaging
- 新兴科学和技术趋势 2023年2卷第2期页码：111-125
- 作者机构：
  
  化学生物学与分子工程教育部重点实验室，山西大学分子科学研究所，山西太原 030006
- 作者简介：
  
  [ "岳永康，男，副教授；博士，博士生导师；山西省优秀青年学术带头人。Email：ykyue@sxu.edu.cn" ]
  [ "阴彩霞，女，教授；博士，博士生导师；国家杰出青年科学基金获得者。Email： yincx@sxu.edu.cn" ]
- 基金信息：
  
  国家自然科学基金(22277069;22325703)
- DOI：10.12405/j.issn.2097-1486.2023.02.001
  中图分类号： O657.3;R318
- 纸质出版日期：2023-06-25，
  
  收稿日期：2023-04-20，
  
  修回日期：2023-05-20，
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岳永康,阴彩霞.荧光探针与高信噪比活体荧光成像[J].新兴科学和技术趋势,2023,2(2):111-125.

YUE Yongkang,YIN Caixia.Fluorescent probes for high signal-to-noise ratio in vivo imaging[J].Emerging Science and Technology,2023,2(2):111-125.
岳永康,阴彩霞.荧光探针与高信噪比活体荧光成像[J].新兴科学和技术趋势,2023,2(2):111-125. DOI： 10.12405/j.issn.2097-1486.2023.02.001.

YUE Yongkang,YIN Caixia.Fluorescent probes for high signal-to-noise ratio in vivo imaging[J].Emerging Science and Technology,2023,2(2):111-125. DOI： 10.12405/j.issn.2097-1486.2023.02.001.

摘要

荧光探针基于荧光染料功能化修饰，实现对生物大分子、活性氧物种、活性硫物种、金属离子等物质的荧光检测。其非破坏性标记和检测属性使得他们在生命科学领域研究中备受青睐。近年来，随着染料精细化工、有机合成化学和荧光成像技术的共同创新，荧光成像在活体原位标记中不断取得新突破，有力地推动了活体荧光成像技术从基础研究向临床前应用迈进。本文中，我们将从荧光探针的基本概念出发，结合我们团队和其他同行的代表性研究成果，讨论荧光探针与活体荧光成像信噪比的相关性，展望其在促进生命科学领域分子水平认知的应用前景。

Abstract

Fluorescent probes can detect biological macromolecules， active oxygen species， active sulfur species， metal ions， etc. via fluorescence signal changes of the functional modification of fluorescent dyes. Their non-destructive labeling and detecting properties are favored by life science researchers. In recent years， with the joint innovation of dye chemical industry， organic synthetic chemistry and fluorescence imaging technology， fluorescence imaging has continuously made new breakthroughs in

in situ

labeling

in vivo

， which has effectively promoted the development of fluorescence imaging technology from basic research to pre-clinical application. This paper starts from the basic concept of fluorescent probe， combined with the representative research results of our team and others. It discusses the correlation between fluorescent probes and the signal-to-noise ratio of fluorescence imaging

in vivo

， and the application prospects of promoting molecular level cognition in life science.

关键词

荧光探针荧光成像信噪比动物活体

Keywords

fluorescent probefluorescence imagingsignal-to-noise ratioin vivo

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