纳米医学研究现状及未来发展前景的探索与思考

容烁; 张瑞平

doi:10.12405/j.issn.2097-1486.2022.01.009

您当前的位置：

首页 >

文章列表页 >

纳米医学研究现状及未来发展前景的探索与思考

其他 | 更新时间：2024-11-01

- 纳米医学研究现状及未来发展前景的探索与思考
- Research status and future prospects of nanomedicine
- 新兴科学和技术趋势 2022年1卷第1期页码：88-96
- 作者机构：
  
  1.山西医科大学　医学科学院，山西　太原　030012
  2.山西医科大学　第一医院，山西　太原　030001
- 作者简介：
  
  [ "容烁，女，讲师，工学博士；山西医科大学医学科学院专职科研教师，山西省抗癌协会纳米肿瘤专业委员会委员，Nano Biom edicine and Engineering期刊编委；主要研究方向为纳米医学和分子生物学，以纳米技术为平台，合成多功能纳米探针或药物，实现了纳米药物治疗的同时进行药物代谢和作用的机理研究，对于推动纳米药物向临床转化具有现实意义；参与国家自然科学基金国际合作项目、重点项目、面上项目等4项，主持山西省应用基础研究计划项目1项；发表高质量文章十余篇，其中SCI 1区2篇。E-mail：qs20060606@163.com" ]
  [ "张瑞平，男，教授；博士，博士生导师；山西医科大学第一医院院长，国家“万人计划”领军人才，全国杰出专业技术人才，国家百千万工程人才，国家卫生健康突出贡献中青年专家，国家自然基金委员会一审、二审专家，山西省重点实验室主任，山西省抗癌协会纳米肿瘤专业委员会主任委员，中国抗癌协会纳米肿瘤学专业委员会常务委员，中国抗癌协会青年常务理事，中华医学会放射学分会分子影像学组委员，山西省医学会肿瘤学专业委员会副主任委员，山西省抗癌协会纳米肿瘤学专业委员会主任委员。", "以分子影像学和纳米医学为研究方向，实现了细胞、分子水平的成像，并以纳米颗粒为载体，合成了多种多功能纳米探针，实现了多模态分子成像和诊疗一体化，对于推动纳米药物向临床转化具有现实意义；近年承担国家自然基金重点项目、面上项目5项；发表SCI收录文章80多篇，部分发表在Natrue Communications，Adv Mater，PNAS，JACS，Chemical Science，ACS Nano，Biomaterials等；以第一完成人获山西省自然科学技术一等奖2项和中国抗癌协会二等奖，还获得了山西省科技进步二等奖3项和三等奖2项，山西省教学成果二等奖2项，山西省高等学校科技一、二等奖。E-mail：zrp7142@sxmu.edu.cn" ]
- 基金信息：
  
  国家自然科学基金项目(8211001138;82071987;81771907;8211001138)
- DOI：10.12405/j.issn.2097-1486.2022.01.009
  中图分类号： R737
- 纸质出版日期：2022-09，
  
  收稿日期：2022-03-11，
  
  修回日期：2022-04-29，
- 稿件说明：
移动端阅览
容烁,张瑞平.纳米医学研究现状及未来发展前景的探索与思考[J].新兴科学和技术趋势,2022,1(1):88-96.

RONG Shuo, ZHANG Ruiping. Research status and future prospects of nanomedicine. [J]. Emerging Science and Technology, 2022,1(1):88-96.
容烁,张瑞平.纳米医学研究现状及未来发展前景的探索与思考[J].新兴科学和技术趋势,2022,1(1):88-96. DOI： 10.12405/j.issn.2097-1486.2022.01.009.

RONG Shuo, ZHANG Ruiping. Research status and future prospects of nanomedicine. [J]. Emerging Science and Technology, 2022,1(1):88-96. DOI： 10.12405/j.issn.2097-1486.2022.01.009.

摘要

纳米医学是将纳米科学与技术的原理与方法应用于医学领域，涉及医学、材料学、物理学、化学、生物学、量子力学等众多领域的综合性交叉学科。本文主要从四方面总结和展示了近年来国内外科研工作者在纳米医学研究领域中取得的最新进展，并对未来发展前景进行了探索与思考：（1）几何和力学性能在纳米药物合理设计中的作用；（2）纳米药物与免疫相关补体系统的相互作用；（3）纳米药物通过优化递送策略治疗肿瘤；（4）基于纳米医学和治疗诊断学的患者分层在个性化纳米药物开发中的关键作用。旨在为纳米医学领域的科研临床工作者提供一些参考。

Abstract

Nanomedicine is a comprehensive interdiscipline that applies the principles and methods of nanoscience and nanotechnology to the medical field

involving a variety of academic disciplines such as medicine

materials science

physics

chemistry

biology

and quantum science.This article mainly summarizes the latest research progress at home and abroad and discusses the future prospects of the nanomedicine research from four aspects: (1) The role of geometric and mechanical properties in the rational design of nanomedicines; (2) Interaction of nanomedicines with the immune-related complement system; (3) Nanomedicines for oncotherapy through optimized delivery strategies; (4) The critical role of patient stratification based on nanomedicine and theranostics in the personalized nanomedicine development.The study aims to provide some references for the scientific and clinical researchers in the field of nanomedicine.

关键词

纳米医学肿瘤治疗治疗诊断学

Keywords

nanomedicineoncotherapytheranostics

references

GADEKAR V, BORADE Y, KANNAUJIA S, et al. Nanomedicines accessible in the market for clinical interventions[J]. Journal of Controlled Release, 2021, 330: 372-397. doi: 10.1016/j.jconrel.2020.12.034http://doi.org/10.1016/j.jconrel.2020.12.034.

MANZARI M T, SHAMAY Y, KIGUCHI H, et al. Targeted drug delivery strategies for precision medicines[J]. Nature Reviews Materials, 2021, 6(4): 351-370. doi: 10.1016/j.jconrel.2020.12.034http://doi.org/10.1016/j.jconrel.2020.12.034.

LI R O, ZHENG D W, HAN Z Y, et al. mHealth: A smartphone-controlled, wearable platform for tumour treatment[J]. Materials Today, 2020, 40: 91-100.

MITRAGOTRI S, ANDERSON D G, CHEN X, et al. Accelerating the translation of nanomaterials in biomedicine[J]. ACS nano, 2015, 9(7): 6644-6654.

PEER D, KARP J M, HONG S, et al. Nanocarriers as an emerging platform for cancer therapy[J]. Nature nanotechnology, 2007, 2(12): 751-760.

LEE A, DI MASCOLO D, FRANCARDI M, et al. Spherical polymeric nanoconstructs for combined chemotherapeutic and anti-inflammatory therapies[J]. Nanomedicine: Nanotechnology, Biology and Medicine, 2016, 12(7): 2139-2147. doi: 10.1038/s41578-020-00269-6http://doi.org/10.1038/s41578-020-00269-6.

STIGLIANO C, KEY J, RAMIREZ M, et al. Radiolabeled polymeric nanoconstructs loaded with docetaxel and curcumin for cancer combinatorial therapy and nuclear imaging[J]. Advanced Functional Materials, 2015, 25(22): 3371-3379.

LU Y, STUREK M, PARK K. Microparticles produced by the hydrogel template method for sustained drug delivery[J]. International journal of pharmaceutics, 2014, 461(1-2): 258-269.

KAI M P, KEELER A W, Perry J L, et al. Evaluation of drug loading, pharmacokinetic behavior, and toxicity of a cisplatin-containing hydrogel nanoparticle[J]. Journal of Controlled Release, 2015, 204: 70-77.

LIU Y, WANG Z, LIU Y, et al. Suppressing nanoparticle-mononuclear phagocyte system interactions of two-dimensional gold nanorings for improved tumor accumulation and photothermal ablation of tumors[J]. ACS nano, 2017, 11(10): 10539-10548. doi: 10.1016/j.nano.2016.05.012http://doi.org/10.1016/j.nano.2016.05.012.

MOGHIMI S M, SIMBERG D, PAPINI E, et al. Complement activation by drug carriers and particulate pharmaceuticals: Principles, challenges and opportunities[J]. Advanced drug delivery reviews, 2020, 157: 83-95.

TAVANO R, GABRIELLI L, LUBIAN E, et al. C1q-mediated complement activation and C3 opsonization trigger recognition of stealth poly(2-methyl-2-oxazoline)-coated silica nanoparticles by human phagocytes[J]. ACS nano, 2018, 12(6): 5834-5847. doi: 10.1021/acsnano.8b01806http://doi.org/10.1021/acsnano.8b01806.

CHEN F, WANG G, GRIFFIN J I, et al. Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo[J]. Nature nanotechnology, 2017, 12(4): 387-393. doi: 10.1038/NNANO.2016.269http://doi.org/10.1038/NNANO.2016.269.

ZHA H, WANG X, ZHU Y, et al. Intracellular activation of complement C3 leads to PD-L1 antibody treatment resistance by modulating tumor-associated macrophages[J]. Cancer immunologyresearch, 2019, 7(2): 193-207. doi: 10.1016/j.nano.2016.05.012http://doi.org/10.1016/j.nano.2016.05.012.

MOGHIMI S M. Nanomedicine safety in preclinical and clinical development: focus on idiosyncratic injection/infusion reactions[J]. Drug discovery today, 2018, 23(5): 1034-1042.

WIBROE P P, ANSELMO A C, NILSSON P H, et al. Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes[J]. Nature nanotechnology, 2017, 12(6): 589-594.

PANNUZZO M, ESPOSITO S, WU L P, et al. O-vercoming nanoparticle-mediated complement activation by surface PEG pairing[J]. Nano letters, 2020, 20(6): 4312-4321.

ZHENG K H, SCHOORMANS J, STIEKEMA L C A, et al. Plaque permeability assessed with DCEMRI associates with USPIO uptake in patients with peripheral artery disease[J]. JACC: Cardiovascular Imaging, 2019, 12(10): 2081-2083. doi: 10.1016/j.jcmg.2019.04.014http://doi.org/10.1016/j.jcmg.2019.04.014.

ZHENG K H, KAISER Y, POEL E, et al. 99mTcfucoidan as diagnostic agent for P-selectin imaging: first-in-human evaluation(phase I)[J]. Atherosclerosis, 2019, 287: e143.

WALL A, NICHOLLS K, CASPERSEN M B, et al. Optimised approach to albumin-drug conjugates using monobromomaleimide-C-2 linkers[J]. Organic&biomolecular chemistry, 2019, 17(34): 7870-7873.

HOWARD K A, DONG M, OUPICKY D, et al. Nanocarrier Stimuli-Activated Gene Delivery[J]. Small, 2007, 3(1): 54-57.

WILHELM S, TAVARES A J, DAI Q, et al. Analysis of nanoparticle delivery to tumours[J]. Nature reviews materials, 2016, 1(5): 1-12.

ROSENBLUM D, PEER D. Omics-based nanomedicine: the future of personalized oncology[J]. Cancer letters, 2014, 352(1): 126-136. doi: 10.1016/j.canlet.2013.07.029http://doi.org/10.1016/j.canlet.2013.07.029.

SAHA R N, VASANTHAKUMAR S, BENDE G, et al. Nanoparticulate drug delivery systems for cancer chemotherapy[J]. Molecular membrane biology, 2010, 27(7): 215-231.

VAN VLERKEN L E, DUAN Z, LITTLE S R, et al. Biodistribution and pharmacokinetic analysis of Paclitaxel and ceramide administered in multifunctionalpolymer-blendnanoparticlesindrugresistant breast cancer model[J]. Molecular pharmaceutics, 2008, 5(4): 516-526.

CUI Y, ZHANG M, ZENG F, et al. Dual-targeting magnetic PLGA nanoparticles for codelivery of paclitaxel and curcumin for brain tumor therapy[J]. ACS Applied Materials & Interfaces, 2016, 8(47): 32159-32169. doi: 10.1021/acsami.6b10175http://doi.org/10.1021/acsami.6b10175.

PEER D, MARGALIT R. Tumor-targeted hyaluronan nanoliposomes increase the antitumor activity of liposomal doxorubicin in syngeneic and human xenograft mouse tumor models[J]. Neoplasia (New York, NY), 2004, 6(4): 343-353.

BOGART L K, POURROY G, MURPHY C J, et al. Nanoparticles for imaging, sensing, and therapeutic intervention[J]. ACS nano, 2014, 8(4): 3107-3122.

ALEXIS F, PRIDGEN E, MOLNAR L K, et al. Factors affecting the clearance and biodistribution of polymeric nanoparticles[J]. Molecular pharmaceutics, 2008, 5(4): 505-515.

CHAUHAN V P, JAIN R K. Strategies for advancing cancer nanomedicine[J]. Nature materials, 2013, 12(11): 958-962.

LEE H, SHIELDS A F, SIEGEL B A, et al. 64Cu-MM-302positronemissiontomographyquantifies variability of enhanced permeability and retention of nanoparticles in relation to treatment response in patients with metastatic breast cancer[J]. Clinical Cancer Research, 2017, 23(15): 4190-4202. doi: 10.1158/1078-0432.CCR-16-3193http://doi.org/10.1158/1078-0432.CCR-16-3193.

YUAN F, DELLIAN M, FUKUMURA D, et al. Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size[J]. Cancer research, 1995, 55(17): 3752-3756.

ERNSTING M J, MURAKAMI M, ROY A, et al. Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles[J]. Journal of controlled release, 2013, 172(3): 782-794.

BARUA S, YOO J W, KOLHAR P, et al. Particle shape enhances specificity of antibody-displaying nan-oparticles[J]. Proceedings of the National Academy of Sciences, 2013, 110(9): 3270-3275.

CABRAL H, MATSUMOTO Y, MIZUNO K, et al. Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size[J]. Nature nanotechnology, 2011, 6(12): 815-823.

LIM J M, SWAMI A, GILSON L M, et al. Ultrahigh throughput synthesis of nanoparticles with homogeneous size distribution using a coaxial turbulent jet mixer[J]. ACS nano, 2014, 8(6): 6056-6065.

DENDUKURI D, PREGIBON D C, CoLLINS J, et al. Continuous-flow lithography for high-throughput microparticle synthesis[J]. Nature materials, 2006, 5(5): 365-369.

LANCET J E, UY G L, CORTES J E, et al. CPX-351(cytarabine and daunorubicin)liposome for injection versus conventional cytarabine plus daunorubicin in older patients with newly diagnosed secondary acute myeloid leukemia[J]. Journal of Clinical Oncology, 2018, 36(26): 2684-2692. doi: 10.1200/JCO.2017.77.6112http://doi.org/10.1200/JCO.2017.77.6112.

ADAMS D, GONZALEZ-DUARTE A, O′RIORDAN W D, et al. Patisiran, an RNAi therapeutic, for hereditary transthyretin amyloidosis[J]. New england journal of medicine, 2018, 379(1): 11-21.

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

暂无数据